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目的 探讨基于4因子的纤维化指数(FIB-4)与老年原发性高血压患者左心室舒张功能的相关性。方法 回顾性分析2021年12月至2022年10月河北省人民医院收治的老年高血压患者183例，根据左心室舒张功能分为左心室舒张功能不全(LVDD)组80例与对照组103例。根据FIB-4最佳临界值，将所有入组者分为高FIB-4(FIB-4≥1.779)组73例和低FIB-4(FIB-4<1.779)组110例。比较LVDD组和对照组FIB-4、血液生化及超声心动图等指标。结果 LVDD组FIB-4高于对照组，高FIB-4组LVDD检出率高于低FIB-4组(P<0.01)。Spearman相关性分析显示，FIB-4与年龄、肺动脉收缩压、舒张早期二尖瓣血流峰值速度(E)与舒张早期二尖瓣瓣环峰值速度(e′)比值(E/e′)、LVDD呈正相关(P<0.05,P<0.01),LVDD与年龄、左心房内径、E/e′呈正相关(P<0.01)。Logistic回归分析显示，LVDD组FIB-4升高的风险是对照组的4.444倍(95%CI:2.165～9.124,P=0.000)。结论 FIB-4有助于反映老年高血压患者LVDD,对评估老年高血压患者发生LVDD风险有一定的实用价值。
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基本信息:
中图分类号:R544.1
引用信息:
[1]孟烨,汪妍,刘英芳,等.老年高血压患者左心室舒张功能与基于4因子的纤维化指数相关性研究[J].中华老年心脑血管病杂志,2024,26(01):97-99.
基金信息:
河北省重点研发计划项目(19277787D); 河北省创新能力提升计划(199776249D); 河北省医学科学研究课题计划(20220061)
2024-01-15
2024-01-15