| 3,176 | 366 | 117 |
| 下载次数 | 被引频次 | 阅读次数 |
目的探讨脑卒中后认知障碍(PSCI)在中国的流行病学情况,为开展预防及治疗提供基础数据。方法通过系统检索中国生物医学文献数据库、中国期刊全文数据库、中国科技期刊数据库、万方数据库等中文数据库及PubMed、荷兰医学文摘和The Cochrane Library(2012年第2期)等英文数据库,纳入有关PSCI在中国的流行病学研究,主要提取发病率、患病率、死亡率等。使用META-ANALYST软件,采用广义倒方差模型对原始数据进行合并分析。结果共纳入35篇文献,13篇文献报道PSCI的发病率总样本量为2332例,18篇文献报道PSD发病率总样本量4468例。脑卒中后≤3个月PSCI和脑卒中后痴呆(PSD)的发病率分别为56.6%和23.2%。PSCI和PSD的患病率为37.9%和19.0%。PSD的1.5年死亡率为50.0%,高于脑卒中后非痴呆患者的8.0%(χ2=156.25,P<0.01)。结论我国PSCI的发病率、患病率和死亡率均较高,发病率有时间、地区分布特征。诊断标准、研究现场、脑卒中及人口学特征是PSCI流行病学的重要影响因素。
Abstract：Objective To provide the basic data for the prevention and treatment of post stroke cognitive impairment by studying its epidemiology in China.Methods Papers on epidemiology of post stroke cognitive impairment in China covered in CBM,CNKI,VIP,Wanfang,PubMed,EMBASE,and Issue 2of 2012Cochrane library were retrieved.The prevalence,incidence and mortality of post stroke cognitive impairment were analyzed using the META-ANALYST software in a generalized variance model.Results The incidence of post stroke cognitive impairment and post stroke dementia was 56.6%and 23.2%,respectively,within 3months after stroke.The morbidity of post stroke cognitive impairment and post stroke dementia was 37.9%and 19.0%,respectively.The mortality of post stroke dementia was significantly higher than that of post stroke non-dementia in 18months after ischemic stroke(50.0%vs 8.0%,χ2=156.25,P<0.01).Conclusion The prevalence,incidence and mortality of post stroke cognitive impairment are rather high in China.The incidence of post stroke cognitive impairment is characterized by the time and district distribution.Diagnostic criteria,study field,ischemic stroke and demographic characteristics are the significant influencing factors for post stroke cognitive impairment.
[1]段建钢.脑卒中后认知障碍的最新循证医学证据.中国现代神经疾病杂志,2009,9:423-427.
[2]血管性认知功能损害专家共识组.血管性认知功能损害的专家共识.中华内科杂志,2007,46:1052-1055.
[3]Prins J,Blanker MH,Bohnen AM,et al.Prevalence of erectile dysfunction:a systematic review of population-based studies.Int J Impot Res,2002,14:422-432.
[4]Sutton AJ,Abrams KR,Jones DR,et al.Methods for Meta Analysis in Medical Research.Wiley,2000.348.
[5]徐晓云,王德生,赵庆杰,等.急性缺血性卒中时的智能障碍及成因研究.当代医师杂志,1996,1:7-9.
[6]单培彦,王淑贞,焉传祝,等.血管性痴呆相关因素的分析.中风与神经疾病杂志,1999,16:367-368.
[7]刘举祥,张冬梅,蒋建章,等.老年人脑卒中后痴呆危险因素分析.中国实用内科杂志,2000,20:725-726.
[8]刘晓林,路屹,李强,等.脑卒中后血管性认知功能损害的临床观察.解剖与临床,2005,10:222-223.
[9]王利平,王鑫,南光贤.脑梗死后血管性认知障碍的临床观察.中国实验诊断学,2008,12:669-671.
[10]李倬.脑卒中与血管性认知功能障碍的相关性研究.宁夏医科大学,2009.44.
[11]杨百瑜.中国12城市45岁以上居民首发卒中后认知损害调查.北京协和医学院,2009.104.
[12]赵东肖.脑梗死后认知障碍与梗塞部位的相关性研究.中国医科大学,2010.36.
[13]滕丹阳,郑健.缺血性脑血管病认知推理障碍的研究.中国实用神经疾病杂志,2009,12:9-11.
[14]罗红波,杨金升,石向群,等.50岁以上患者卒中后认知功能损害及生活质量的研究.中国脑血管病杂志,2009,6:528-531.
[15]Chen YK,Mok VCT,Wong KS,et al.Vascular cognitive impairment in Chinese ischemic stroke patients.J Neurol Sci,2009,285:S284.
[16]高薇薇.血管性认知功能障碍相关因素分析及事件相关电位和局部脑血流灌注的临床研究.天津医科大学,2010.71.
[17]杨艳,谭泽峰,徐安定,等.无症状性脑梗死对首发急性缺血性卒中患者认知功能的影响.中国神经精神疾病杂志,2011,37:584-587.
[18]王新德,陈海波,蔡晓杰.老年人脑血管性痴呆的研究.中华老年医学杂志,1992,11:138-141.
[19]李炎生,谢敦祥.长谷川痴呆量表在老年人血管性痴呆中的应用.衡阳医学院学报,1997,25:156-157.
[20]范薇,朱文炳,汪昕.腔隙性脑梗塞后痴呆发病的初步研究.中国临床神经科学,2000,8:134-135.
[21]何育生,王星,陈辉新,等.脑梗死后痴呆的临床分析.中风与神经疾病杂志,2001,18:226-228.
[22]赵玮琳,朱敏嘉,吴京平,等.脑卒中所致的抑郁与血管性痴呆的分析——附84例报告.新医学,2001,32:466-467.
[23]易艳辉,彭海峰,周仕钧,等.脑卒中后痴呆的相关因素探讨.中国医师杂志,2002,4:643-644.
[24]邓雪珍,叶惠淑.血管性痴呆的发生率及相关因素.心血管康复医学杂志,2002,11:167-168.
[25]王新.脑卒中致血管性痴呆临床分析.临床医学,2002,22:19-20.
[26]毛善平,叶心国,唐尊立,等.从卒中到VD的动态CT分析.武汉大学学报,2002,23:234-237.
[27]钟维章,蔺心敬,宁加玲,等.首次脑卒中后血管性痴呆的发生与病变部位的关系.中国临床康复,2004,8:5238-5239.
[28]Zhou DH,Wang JY,Li J,et al.Study on frequency and predictors of dementia after ischemic stroke:the Chongqing stroke study.J Neurol,2004,251:421-427.
[29]张春燕,吴腾,阿拉腾,等.首次缺血性卒中后痴呆发生率及其危险因素.中国心理卫生杂志,2005,19:697-698.
[30]Li JC,Zhou HD,Wang YJ,et al.Impact of post-stroke dementia on the survival rate of the patients.Chinese Journal of Clinical Rehabilitation,2005,9:156-158.
[31]周晓辉,张小宁,郝晨光,等.新疆地区维吾尔族和汉族50岁以上人群脑卒中及血管性痴呆流行病学调查.中华流行病学杂志,2008,29:1049-1050.
[32]刘茜.脑卒中所致的抑郁与血管性痴呆的分析——附102例报告.中国现代临床医学,2008,7:1-3.
[33]张新庆,倪小青,王崇屹,等.脑卒中与卒中后痴呆相关性研究.现代康复,2001,5:58.
[34]徐群,林岩,耿介立,等.缺血性卒中后认知功能障碍的患病率和危险因素.中华内科杂志,2008,47:981-984.
[35]罗凌芳,袁荣峰,高小平,等.无症状性脑梗死与血管性认知障碍的临床研究.中国医师杂志,2008,10:174-176.
[36]刘宏军,方向华,秦晓明,等.北京市社区缺血性卒中患者认知功能障碍及危险因素调查.中国脑血管病杂志,2009,6:514-518.
[37]涂秋云,杨霞,丁斌蓉,等.缺血性脑卒中后血管性认知障碍的流行病学调查.中国老年学杂志,2011,31:3576-3579.
[38]Pasi M,Poggesi A,Salvadori E,et al.Post-stroke dementia and cognitive impairment.Front Neurol Neurosci,2012,30:65-69.
[39]Pendlebury ST,Rothwell PM.Prevalence,incidence,and factors associated with pre-stroke and post-stroke dementia:a systematic review and meta-analysis.Lancet Neurol,2009,8:1006-1018.
[40]Leys D,Hénon H,Mackowiak-Cordoliani MA,et al.Post stroke dementia.Lancet Neurol,2005,4:752-759.
[41]Makin SD,Turpin S,Dennis MS,et al.Cognitive impairment after lacunar stroke:systematic review and meta-analysis of incidence,prevalence and comparison with other stroke subtypes.J Neurol Neurosurg Psychiatry,2013,84:893-900.
[42]Wong GK,Lam S,Ngai K,et al.Evaluation of cognitive impairment by the Montreal cognitive assessment in patients with aneurysmal subarachnoid haemorrhage:prevalence,risk factors and correlations with 3 month outcomes.J Neurol Neurosurg Psychiatry,2012,83:1112-1117.
[43]Ballard C,Rowan E,Stephens S,et al.Prospective follow-up study between 3and 15 months after stroke:improvements and decline in cognitive function among dementia-free stroke survivors>75years of age.Stroke,2003,34:2440-2444.
[44]贾建平.重视血管性认知障碍的早期诊断和干预.中华神经科杂志,2005,38:4-6.
基本信息:
DOI：
中图分类号:R743.3
引用信息:
[1]曲艳吉,卓琳,詹思延.中国脑卒中后认知障碍流行病学特征的系统评价[J].中华老年心脑血管病杂志,2013,15(12):1294-1301.
基金信息: