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2025, 06, v.27 689-692
α突触核蛋白在帕金森病中的作用
基金项目(Foundation): 国家自然科学基金(82271447)
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<正>帕金森病(Parkinson'sdisease,PD)是第二常见的神经退行性疾病,预计全球有超过1000万人罹患PD[1]。PD的发病风险与年龄呈正相关,随着人口老龄化的加剧,其发病率逐年增加[2]。PD的症状包括运动迟缓、肌强直、静止性震颤等运动症状,以及自主神经功能障碍、睡眠障碍、嗅觉障碍、情绪和认知障碍等非运动症状[3]。PD特征性的病理改变是黑质致密部多巴胺能神经元的变性丢失,残存神经元内形成路易小体[4]。路易小体的主要成分是异常聚集的α突触核蛋白(α-Synuclein,α-Syn),生理状态下α-Syn为可溶性蛋白,但在PD患者脑内α-Syn发生聚集形成病理性聚集体,并在神经元之间传播,导致神经损伤[4-5]。越来越多的研究发现,α-Syn的异常聚集和传播在PD发生中发挥关键作用,当前研究的重点包括解析α-Syn聚集和毒性作用的机制,并针对α-Syn开发新的诊断和治疗方法。

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参考文献

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中图分类号:R742.5

引用信息:

[1]张振涛.α突触核蛋白在帕金森病中的作用[J].中华老年心脑血管病杂志,2025,27(06):689-692.

基金信息:

国家自然科学基金(82271447)

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