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目的 采用决策曲线和剂量反应分析信号肽-CUB-表皮生长因子结构域包含蛋白1(signal peptide-CUB-epidermal growth factor-like domain-containing protein 1,SCUBE1)和血清纽蛋白(Vinculin)与老年心肌梗死(acute myocardial infarction, AMI)患者经皮冠状动脉介入治疗(percutaneous coronary intervention, PCI)术后心肌损伤的预测价值。方法 前瞻性选取2021年1月至2024年1月浙江中医药大学附属湖州市中医院重症医学科收治的老年AMI患者68例为观察组，并同期选择60例健康体检者为对照组；根据随访3个月后是否发生主要心血管不良事件(major adverse cardiovascular events, MACE)将观察组分为MACE组32例和未发生MACE组36例。检测患者血清SCUBE1、Vinculin含量、血清中肌钙蛋白I(troponin I,cTnI)、肌酸激酶同工酶(creatine kinase isoenzymes-MB,CK-MB)和肌红蛋白(myoglobin, Myo)。采用Pearson相关性分析SCUBE1、Vinculin与cTnI、CK-MB、Myo表达相关性。采用ROC曲线分析SCUBE及Vinculin对老年AMI患者PCI预后的预测价值。采用限制性立方样条图分析血清SCUBE1和Vinculin与老年AMI患者PCI术后发生MACE事件关联强度的剂量反应。采用决策曲线分析血清SCUBE1和Vinculin对老年AMI患者PCI术后发生MACE事件预测价值。结果 观察组cTnI、CK-MB、Myo、SCUBE1和Vinculin表达高于对照组，差异有统计学意义(P<0.01)。Pearson相关性分析结果显示，观察组SCUBE1、Vinculin与cTnI、CK-MB、Myo表达呈正相关；发生组血清SCUBE1和Vinculin水平高于未发生组；ROC曲线分析结果显示，血清SCUBE1和Vinculin预测老年AMI患者PCI术后MACE发生的曲线下面积为0.783、0.814,两者联合预测老年AMI患者PCI术后MACE发生的曲线下面积为0.959;血清SCUBE1和Vinculin连续变化与老年AMI患者PCI术后发生MACE事件呈非线性剂量反应关系(r=0.698,r=0.832,P<0.001),血清SCUBE1和Vinculin与老年AMI患者PCI术后发生MACE事件呈显著正相关，老年AMI患者PCI术后发生MACE概率随血清SCUBE1和Vinculin升高而升高；血清SCUBE1和Vinculin对老年AMI患者PCI术后发生MACE事件发生具有一定预测价值。结论 SCUBE1和Vinculin与老年AMI患者PCI术后心肌损伤发生存在相关性，且具有较好的预测价值。
Abstract：[1] Berg RMG,Jabbari R.The Bezold-Jarisch reflex:hubris and (n) emesis in the clinical assessment of acute inferior wall myocardial infarction[J].Exp Physiol,2025,110(8):1026-1028.DOI:10.1113/EP092587.
[2] Godo S,Yasuda S.New landscape of acute myocardial infarction complicated by cardiogenic shock with the advent of a small but mighty heart pump[J].Circ J,2023,87(5):598-599.DOI:10.1253/circj.CJ-23-0085.
[3] Ayyappan S,Shekhawat RS,Meshram VP,et al.Spontaneous retroperitoneal and intracranial hemorrhage following streptokinase therapy in acute myocardial infarction:an autopsy case report[J].J Forensic Sci,2024,69(1):346-350.DOI:10.1111/1556-4029.15418.
[4] Tufekci D,Nuhoglu I,Ayan SS,et al.Can signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) be used as an indicator of endothelial dysfunction in acromegaly patients?[J].Endocrine,2023,82(1):152-160.DOI:10.1007/s12020-023-03444-1.
[5] Bonacina F,Danilo Norata G.Vinculin phosphorylation modulates endothelial cell permeability:a new target for cardiovascular disease?[J].Eur Heart J,2022,44(4):319-321.DOI:10.1093/eurheartj/ehac704.
[6] 王洋，龚燕平.2019年ESC联合EASD对糖尿病前期、糖尿病、心血管疾病指南的解读[J].中国循证心血管医学杂志，2020,12(5):516-518.DOI:10.3969/j.issn.1674-4055.2020.05.02.
[7] Xing H,Yang J,Huang M,et al.The potential effective components from Danlou tablet attenuates acute myocardial infarction by restoring ALOX12-mediated perturbed oxylipins[J].J Ethnopharmacol,2025,345:119617.DOI:10.1016/j.jep.2025.119617.
[8] Pedicino D,Volpe M.Weekly Journal Scan:a clear message questions the routine use of spironolactone in acute myocardial infarction[J].Eur Heart J,2025,46(14):1359-1360.DOI:10.1093/eurheartj/ehae936.
[9] Khedri M,Szummer K,Lundman P,et al.Statin treatment intensity,discontinuation and long-term outcome in patients with acute myocardial infarction and impaired kidney function[J].J Cardiovasc Pharmacol,2023,81(6):400-410.DOI:10.1097/FJC.0000000000001402.
[10] Thiele H,Belohlavek J,Hassager C.Routine venoarterial extracorporeal membrane oxygenation for acute myocardial infarction-related cardiogenic shock:what we know and don't know[J].Intensive Care Med,2024,50(8):1354-1357.DOI:10.1007/s00134-024-07517-1.
[11] Eitel I,Saraei R,Jurczyk D,et al.Glycoprotein Ⅱb/Ⅲa Inhibitors in acute myocardial infarction and angiographic microvascular obstruction:the reverse-flow trial[J].Eur Heart J,2024,45(47):5058-5067.DOI:10.1093/eurheartj/ehae587.
[12] Zhang L,Liu Y,Yang C,et al.Clinical efficacy and therapy response prediction of neoadjuvant dalpiciclib plus letrozole in postmenopausal patients with HR+/HER2- stage Ⅱ-Ⅲ breast cancer (DARLING 01):a single-arm,open-label,exploratory study[J].Breast Cancer Res,2025,27(1):21.DOI:10.1186/s13058-025-01976-0.
[13] 钟婉红，许俊旭，王聪，等.OLFM-4,SCUBE-1联合L-FABP对重症肺炎患者并发急性肾损伤的早期诊断价值[J].中国医师杂志，2024,26(8):1186-1190.DOI:10.3760/cma.j.cn431274-20230915-00270.
[14] Yamak BA,Candemir M,K?z?ltun? E,et al.Evaluating SCUBE-1 as predictive biomarker for hypertension-mediated organ damage:a comparative study[J].Rev Cardiovasc Med,2025,26(1):25832.DOI:10.31083/RCM25832.
[15] Fedai H,Toprak K,Cetin M,et al.The assessment of the relationship between the development of cardiovascular diseases and SCUBE-1 level in individuals exposed to loud noise[J].Medicine (Baltimore),2024,103(51):e41053.DOI:10.1097/MD.0000000000041053.
[16] Yu X,Wu Z,Zhang N.Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcers[J].Mol Med,2024,30(1):215.DOI:10.1186/s10020-024-00955-z.
[17] 赵景宏，乔彦，张荣驿，等.血清SCUBE1、Lp-PLA2水平与急性STEMI患者冠状动脉高血栓负荷的关系[J].山东医药，2024,64(7):33-37.DOI:10.3969/j.issn.1002-266X.2024.07.007.
[18] 高运霞，高艳玲，高超，等.血清SCUBE1对老年缺血性心力衰竭患者的预后评估研究[J].中国循证心血管医学杂志，2023,15(6):662-666.DOI:10.3969/j.issn.1674-4055.2023.06.05.
[19] 梁保，金志刚，程愿玲，等.血清表皮生长因子结构域包含蛋白1与急性心肌梗死患者血栓负荷及预后的关系[J].中华老年心脑血管病杂志，2023,25(8):818-822.DOI:10.3969/j.issn.1009-0126.2023.08.009.
[20] Shi B,Matsui T,Qian S,et al.An ensemble of cadherin-catenin-Vinculin complex employs Vinculin as the major F-actin binding mode[J].Biophys J,2023,122(12):2456-2474.DOI:10.1016/j.bpj.2023.04.026.
[21] Lubanska D,Soliman MTA,Alrashed S,et al.373Exploring principles of the interplay between cancer stem cells and cancer activated fibroblasts towards advanced therapies against glioblastoma[J].Neurosurgery,2023,69:64-65.DOI:10.1227/neu.0000000000002375_373.
[22] van den Goor L,Iseler J,Koning KM,et al.Mechanosensitive recruitment of Vinculin maintains junction integrity and barrier function at epithelial tricellular junctions[J].Curr Biol,2024,34(20):4677-4691.e5.DOI:10.1016/j.cub.2024.08.060.
[23] Yan M,Zheng H,Yan R,et al.Vinculin identified as a potential biomarker in hand-arm vibration syndrome based on itraq and lc-ms/ms-based proteomic analysis[J].J Proteome Res,2023,22(8):2714-2726.DOI:10.1021/acs.jproteome.3c00277.
[24] Sakai Y,Shimizu T,Tsunekawa M,et al.Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans[J].PLoS Genet,2023,19(12):e1011089.DOI:10.1371/journal.pgen.1011089.
[25] Dawkins S,Digby JE,Belgard TG,et al.Stratification of acute myocardial and endothelial cell injury,salvage index and final infarct size by systematic microRNA profiling in acute ST-elevation myocardial infarction[J].Coron Artery Dis,2024,35(2):122-134.DOI:10.1097/MCA.0000000000001284.
[26] Nv B,McCollum S,Faherty E,et al.Longitudinal assessment of left ventricular function in patients with myopericarditis after mRNA COVID-19 vaccination[J].Pediatr Cardiol,2024,45(7):1524-1532.DOI:10.1007/s00246-023-03200-2.
[27] El Feky W,El-Afify D,Abdelhai D,et al.L-carnitine decreases myocardial injury in children undergoing open-heart surgery:a randomized controlled trial[J].Eur J Pediatr,2024,183(6):2783-2789.DOI:10.1007/s00431-024-05534-2.
基本信息:
中图分类号:R542.22
引用信息:
[1]杨思思,迟永生,况珊,等.信号肽-CUB-表皮生长因子结构域包含蛋白1和纽蛋白与心肌梗死患者心肌损伤的关系[J].中华老年心脑血管病杂志,2025,27(10):1419-1422.
基金信息:
浙江省医学会临床科研基金项目(2022ZYC-A67)
2025-09-29
2025-09-29