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目的对认知障碍初步评价表(COG-12)在阿尔茨海默病(AD)患者中的信度与效度进行评价。方法选择2013年1~12月就诊于南京医科大学附属脑科医院老年精神科的AD患者148例为AD组,另选择社区志愿者365例为对照组,2组均接受临床痴呆量表、AD8、简易智能状态检查量表、画钟测验评估和COG-12测评。其中100例AD患者知情者在首次评定1个月内重测COG-12。结果 COG-12的克朗巴赫α系数=0.883,重测信度=0.883(P<0.01)。COG-12各条目评分与总分的相关系数为0.410.79(P<0.05,P<0.01);COG-12总分与简易智能状态检量表、画钟测验呈负相关(r=-0.67,r=-0.27,P<0.01),与临床痴呆量表、AD8总分呈正相关(r=0.80,r=0.81,P<0.01)。COG-12鉴别认知正常与轻度AD患者的ROC曲线下面积=0.902,≥6分为认知损害的界限分值敏感性为90.0%,特异性为82.5%;鉴别轻度与中度AD患者的ROC曲线下面积=0.898,敏感性为90.5%,特异性为76.7%。结论 COG-12具有良好的信度和效度,是快速识别痴呆及评估严重程度敏感而准确的筛查评估工具。
Abstract：Objective To assess the validity and reliability of COG-12 in Alzheimer's disease(AD)patients.Methods One hundred and forty-eight AD patients served as an AD group and 365 volunteers served as a control group in this study.Patients in two groups were assessed according to the AD8,CDR,MMSE,CDT and COG-12,respectively.Of the 148 AD patients,100 were reassessed according to the COG-12.Results The Cronbach alpha coefficient and retested intraclass correlation coefficient for COG-12 were 0.883 and 0.883,respectively(P<0.01).The correlation coefficient for each COG-12 item score and total COG-12 score was 0.41-0.79(P<0.05,P<0.01).The total COG-12 score was negatively correlated with the MMSE and CDT,and positively correlated with the total CDR and AD8score(r=-0.67,r=-0.27,P<0.01;r=0.80,r=0.81,P<0.01).The area under the ROC curve was 0.902 when those with normal recognition and mild AD patients were identified according to the COG-12 with a sensitivity of 90.0%and a specificity of 82.5% when its cutoff was≥6.The area under the ROC curve was 0.898 when the mild and moderate AD patients were identified according to the COG-12 with a sensitivity of 90.5%and a specificity of 76.7%.Conclusion COG-12,with a good validity and reliability,is a sensitive and accurate tool for the rapid screen of dementia and assessment of its severity.
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基本信息:
中图分类号:R749.1
引用信息:
[1]梅刚,公丕裕,罗群,等.认知障碍初步评价表信度与效度的初步研究[J].中华老年心脑血管病杂志,2014,16(10):1044-1047.
基金信息:
国家自然科学基金(81271211,30700248);; 国家临床重点专科建设项目(2011-873);; 南京市医学重点学科和重点人才项目(2012-75,2012-4);; 江苏省神经退行性疾病重点实验室开放课题(SJ11KF05);; 江苏省科技支撑计划(BK2009049)
2014-10-15
2014-10-15