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<正>我国脑卒中负担沉重,且其中1/3患者可并发脑卒中后认知障碍(post stroke cognitive impairment,PSCI)[1]。PSCI是指在脑卒中事件后出现并持续到6个月时仍存在的以认知损害为特征的临床综合征,表现为注意力、执行功能及记忆力等多认知领域功能受损,按认知损害的严重程度及日常生活能力(activity of daily living,ADL)是否受损分为脑卒中后痴呆和PSCI非痴呆[2]。
Abstract:[1]中国卒中学会血管性认知障碍分会.中国血管性认知障碍诊治指南(2024版)[J].中华医学杂志,2024,104(31):2881-2894. DOI:10.3760/cma.j.cn112137-20240501-01024.
[2]汪凯,董强.卒中后认知障碍管理专家共识2021[J].中国卒中杂志,2021,16(4):376-389. DOI:10.3969/j.issn.1673-5765.2021.04.011.
[3]胡国艳,谭锻玲,李雨晴,等.BDNF基因多态性与脑卒中认知障碍遗传易感性的相关性[J].分子诊断与治疗杂志,2023,15(12):2219-2223. DOI:10.3969/j.issn.1674-6929.2023.12.044.
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[8]徐沛韬,魏伟,赵雨晴,等.卒中后认知障碍患者认知功能的事件相关电位研究[J].康复学报,2024,34(3):217-224,232. DOI:10.3724/SP.J.1329.2024.03010.
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[10]刘畅,姚明,彭斌.偶然发现弥散加权成像阳性病变在脑小血管病的研究进展[J].中华神经科杂志,2024,57(11):1269-1274.DOI:10.3760/cma.j.cn113694-20240318-00164.
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[14]Zhang H, He K, Zhao Y, et al. fNIRS biomarkers for stratifying poststroke cognitive impairment:evidence from frontal and temporal cortex activation[J]. Stroke, 2025, 56(11):3245-3256. DOI:10.1161/STROKEAHA.124.050269.
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[17]Zhao P, Zhao M, Zhang G, et al. Plasma inflammatory cytokines are associated with cognitive impairment after acute minor ischemic stroke and transient ischemic attack[J]. Front Immunol, 2025, 16:1445938. DOI:10.3389/fimmu.2025.1445938.
[18]Khan R, Devlin P, Urayama A, et al. Models and mechanisms of poststroke dementia and cognitive impairment[J]. Front Stroke, 2025, 4:1563924. DOI:10.3389/fstro.2025.1563924.
[19]安雨琦,罗萌,陈露露,等.TREM2调控小胶质细胞活性参与脑卒中后认知障碍的研究进展[J].生理科学进展,2025,56(1):97-104. DOI:10.20059/j.cnki.pps.2024.08.1061.
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[21]Lee M, Yeo NY, Ahn HJ, et al. Prediction of post-stroke cognitive impairment after acute ischemic stroke using machine learning[J].Alzheimers Res Ther, 2023, 15(1):147. DOI:10.1186/s13195-023-01289-4.
[22]Zhong X, Zhao T, Lv S, et al. Development and validation of a machine learning-based risk prediction model for post-stroke cognitive impairment[J]. Sci Rep, 2025, 15(1):32942. DOI:10.1038/s41598-025-98054-4.
基本信息:
中图分类号:R743.3;R749.1
引用信息:
[1]钱海蓉.卒中后认知障碍的预测因素是早诊早治的关键[J].中华老年心脑血管病杂志,2026,28(02):139-142.
2026-02-12
2026-02-12