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<正>缺血性脑卒中作为神经系统疾病,特征是局部脑血流暂时或永久性减少,其高发病率、高致残率和预后不良给全球社会带来巨大的社会负担[1]。缺血性脑卒中发生后,坏死的神经元释放细胞质双链DNA,这是一种潜在的损伤相关分子模式,可以激活环鸟苷酸-腺苷酸合成酶(cyclic guanosine monophosphate-adenosine monophosphate synthase,cGAS)-干扰素基因刺激蛋白(stimulator of interferon genes,STING)信号通路。cGAS-STING信号通路最初被确定为先天免疫宿主防御系统的关键组成部分,最近被认为是各类炎症疾病发生和发病的关键途径。许多证据表明,先天免疫系统引发的各类病理过程阻碍缺血性脑卒中发生后神经和行为恢复,与缺血性脑卒中发生发展有着密切联系[2]。
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基本信息:
中图分类号:R743.3
引用信息:
[1]黄馨蕾,刘姗姗,吕鹤群,等.缺血性脑卒中研究新思路环鸟苷酸-腺苷酸合成酶-干扰素基因刺激蛋白信号通路[J].中华老年心脑血管病杂志,2025,27(11):1593-1596.
基金信息:
国家自然科学基金(82374565,82174484)
2025-11-15
2025-11-15