| 321 | 7 | 61 |
| 下载次数 | 被引频次 | 阅读次数 |
<正>根据2020年中国心血管健康与疾病报告，心血管疾病在我国发病率及死亡率正逐年攀升，为此，根据早预防早治疗的治病理念开展针对性的心血管疾病预测因子研发具有重大意义[1]。心血管疾病的进展与心肌重构和机体体液调节密不可分。心脏组织可分泌多种生物活性物质，即心脏因子，以自分泌和旁分泌等体液调节方式参与心脏活动的调控，如利钠肽、肾上腺髓质素、蛋白酶抑制剂和卵泡抑素样蛋白1(follistatin-like protein 1,FSTL1)
Abstract：[1] 中国心血管健康与疾病报告编写组，胡盛寿.中国心血管健康与疾病报告2020概要[J].中国循环杂志，2021,36(6):521-545.DOI:10.3969/j.issn.1000-3614.2021.06.001.
[2] Wei K,Serpooshan V,Hurtado C,et al.Epicardial FSTL1 reconstitution regenerates the adult mammalian heart[J].Nature,2015,525(7570):479-485.DOI:10.1038/nature 15372.
[3] Seki M,Powers JC,Maruyama S,et al.Acute and chronic increases of circulating FSTL1 normalize energy substrate metabolism in pacing-induced heart failure[J].Circ Heart Fail,2018,11(1):e004486.DOI:10.1161/CIRCHEARTFAILURE.117.004486.
[4] Prakash S,Mattiotti A,Sylva M,et al.Identifying pathogenic variants in the follistatin-like 1 gene (FSTL1) in patients with skeletal and atrioventricular valve disorders[J].Mol Genet Genomic Med,2019,7(4):e00567.DOI:10.1002/mgg3.567.
[5] Parfenova OK,Kukes VG,Grishin DV.Follistatin-like proteins:structure,functions and biomedical importance[J].Biomedicines,2021,9(8):999.DOI:10.3390/biomedicines908 0999.
[6] Mattiotti A,Prakash S,Barnett P,et al.Follistatin-like 1 in development and human diseases[J].Cell Mol Life Sci,2018,75(13):2339-2354.DOI:10.1007/s00018-018-2805-0.
[7] Ogura Y,Ouchi N,Ohashi K,et al.Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models[J].Circulation,2012,126(14):1728-1738.DOI:10.1161/ CIRCULATIONAHA.112.115089.
[8] Hanna A,Frangogiannis NG.The role of the TGF-β superfamily in myocardial infarction[J].Front Cardiovasc Med,2019,6:140.DOI:10.3389/fcvm.2019.00140.
[9] Chaly Y,Hostager B,Smith S,et al.Follistatin-like protein 1 and its role in inflammation and inflammatory diseases[J].Immunol Res,2014,59(1-3):266-272.DOI:10.1007/s12026-014-8526-z.
[10] Xi Y,Hao M,Liang Q,et al.Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A-Smad2/3 in rats following myocardial infarction[J].J Sport Health Sci,2021,10(5):594-603.DOI:10.1016/j.jshs.2020.11.010.
[11] Liu Y,Wei J,Zhao Y,et al.Follistatin-like protein 1 promotes inflammatory reactions in nucleus pulposus cells by interacting with the MAPK and NF-κB signaling pathways[J].Oncotarget,2017,8(26):43023-43034.DOI:10.18632/oncotarget.17400.
[12] Maruyama S,Nakamura K,Papanicolaou KN,et al.Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture[J].EMBO Mol Med,2016,8(8):949-966.DOI:10.15252/emmm.201506151.
[13] Jiang H,Zhang L,Liu X,et al.Angiocrine FSTL1 (follistatin-like protein 1) insufficiency leads to atrial and venous wall fibrosis via SMAD3 activation[J].Arterioscler Thromb Vasc Biol,2020,40(4):958-972.DOI:10.1161/ ATVBAHA.119.313901.
[14] Dong Y,Geng Y,Li L,et al.Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice[J].J Exp Med,2015,212(2):235-252.DOI:10.1084/jem.20121878.
[15] Hu S,Liu H,Hu Z,et al.Follistatin-like 1:a dual regulator that promotes cardiomyocyte proliferation and fibrosis[J].J Cell Physiol,2020,235(9):5893-5902.DOI:10.1002/jcp.29588.
[16] Peters MC,Di Martino S,Boelens T,et al.Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts[J].Mol Ther Methods Clin Dev,2022,25:3-16.DOI:10.1016/j.omtm.2022.02.005.
[17] Ghim M,Pang KT,Burnap SA,et al.Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation[J].Atherosclerosis,2021,333:56-66.DOI:10.1016/j.atherosclerosis.2021.08.025.
[18] Wang S,Wei J,Shi J,et al.Follistatin-like 1 attenuation suppresses intervertebral disc degeneration in mice through interacting with TNF-α and Smad signaling pathway[J].Oxid Med Cell Longev,2021,2021:6640751.DOI:10.1155/2021/6640751.
[19] Tanaka K,Valero-Muňoz M,Wilson RM,et al.Follistatin-like 1 regulates hypertrophy in heart failure with preserved ejection fraction[J].JACC Basic Transl Sci,2016,1(4):207-221.DOI:10.1016/j.jacbts.2016.04.002.
[20] Shimano M,Ouchi N,Nakamura K,et al.Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload[J].Proc Natl Acad Sci U S A,2011,108(43):E899-E906.DOI:10.1073/pnas.1108559108.
[21] Xi Y,Gong DW,Tian Z.FSTL1 as a potential mediator of exercise-induced cardioprotection in post-myocardial infarction rats[J].Sci Rep,2016,6:32424.DOI:10.1038/srep32424.
[22] Shen H,Cui G,Li Y,et al.Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model[J].Stem Cell Res Ther,2019,10(1):17.DOI:10.1186/s13287-018-1111-y.
[23] Henkel M,Partyka J,Gregory AD,et al.FSTL-1 attenuation causes spontaneous smoke-resistant pulmonary emphysema[J].Am J Respir Crit Care Med,2020,201(8):934-945.DOI:10.1164/rccm.201905-0973OC.
[24] Zhang W,Wang W,Liu J,et al.Follistatin-like 1 protects against hypoxia-induced pulmonary hypertension in mice[J].Sci Rep,2017,7:45820.DOI:10.1038/srep45820.
基本信息:
中图分类号:R54
引用信息:
[1]许文清,刘敏.卵泡抑素样蛋白1在心血管疾病中的研究进展[J].中华老年心脑血管病杂志,2022,24(09):997-999.
基金信息:
国家自然科学基金(81871328); 北京市自然科学基金(7182149)
2022-08-30
2022-08-30